MTHFR Mutation Genotype
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An inherited variant in the enzyme that processes folate and regulates homocysteine.
- Member pricing close to cost, no upsells
- Schedule online, typical results in 6-10 days
- Clear guidance, results reviewed by a real clinician
- Follow-up care available
HSA/FSA eligible
About this test
MTHFR is the gene encoding methylenetetrahydrofolate reductase, the enzyme that converts folate into the active form used to clear homocysteine from the blood. This test identifies the two common variants, C677T and A1298C, that reduce enzyme activity and can raise homocysteine, particularly when folate intake is low. The genotype is a risk factor, not a diagnosis: these variants do not independently raise risk of homocysteine-related conditions unless homocysteine is actually elevated, so measuring total plasma homocysteine is the more useful functional marker. The one situation where the genotype directly informs care is folate-dependent chemotherapy such as methotrexate, where sharing your result with the prescribing physician matters. Major guidelines do not recommend testing these variants to evaluate clotting or pregnancy risk, given limited evidence of clinical utility.
Consider it if
- Elevated homocysteine on a blood test and you want to know whether genetics is contributing
- A family history of MTHFR variants or homocysteine-related concerns
- Planning or undergoing folate-dependent chemotherapy such as methotrexate
- Curious about your folate-processing genetics as a one-time baseline
Why are there member and non-member prices?
Members get Mito's no-markup price on tests. The non-member price is the standard price.
Mito membership is $9/month and unlocks member pricing across the catalog. It's how Mito is supported, so we don't have to mark up your tests or earn more when you buy more. Your member savings are applied at checkout.
Video call with clinician
Speak with a real clinician to discuss your labs.
What's included
What's tested
This test measures a single biomarker: MTHFR gene targeted mutation analysis.
Test details
- Sample type
- Blood sample (or buccal swab)
- Collection
- Partner lab visit
- Preparation
- No fasting required
- Results in
- Typical results in 6-10 days
Pre-test considerations
No fasting or special preparation is needed. This is a genetic test, so the result is fixed for life and never needs repeating. If you also want to know your actual homocysteine level, which is the marker that shows whether the genotype is having any functional effect, that requires a separate blood test.
Results in as little as 1-2 business days
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Results in 1-2 business days
Your results post to your dashboard fast — then a clinician reviews them and your personalized action plan follows.
- 4 Expert guidance
Our clinicians will recommend next steps. Or book a same-day visit for comprehensive care.
Everything your health needs,
in one membership
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Cost-plus on every test you order
Members pay close to cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
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Without membership
$0
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. Your price is our cost plus a small amount to run the service, never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Members pay even less, applied at checkout (membership is $9/mo, and you still pay the lab’s order fee). Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results are typically visible within 1-2 business days of your lab visit. A clinician then reviews them, and your full analysis and personalized action plan — with clear next steps — follow once that review is complete. Specialty assays and at-home kits take longer; each test shows its turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.